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Research Scientist/ Pharmacokineticist in Frederick at General Dynamics Information Technology

Date Posted: 3/7/2019

Job Snapshot

Job Description

General Dynamics Military Health Solutions is hiring a Research Scientist / Pharmacokineticist to support the US Army Medical Research Institute of Infectious Diseases (USAMRIID). In this role, you will support services in the area of pharmacokinetics; molecular biology; pharmacology and related fields. Since its inception in 1969, USAMRIID has spearheaded research to develop medical solutions—vaccines, drugs, diagnostics, and information—to protect our military service members from biological threats.  Our specialized capabilities include Biosafety Level 3 and Level 4 laboratories, world-class expertise in the generation of biological aerosols for testing candidate vaccines and therapeutics, and fully accredited animal research facilities.

Learn More About USAMRIID HERE 

The Scientist will work with clinical pharmacology and pharmacokinetic modeling and relevant software platforms; with high performance liquid chromatography mass spectroscopy (HPLC-MS) sufficient to design and validate assays to determine the concentration of antimicrobial compounds in biological sample; with microbiological, molecular techniques and animal handling (particularly in a BSL-3 environment); will work on projects of high importance, volume and difficulty. Additionally; because of the pathogenic nature of the organisms to be studied; you will execute laboratory techniques with skill and the utmost attention to safety considerations.

Primary Responsibilities: 

  • Design and implement Pharmacology capabilities within the Core Therapeutics section.
  • Design and Execute pharmacokinetic studies on candidate compounds of interest
  • Analyze pharmacokinetic data and provide a pharmacokinetic report to laboratory lead scientist.
  • Develop and validate high performance liquid chromatography mass spectroscopy (HPLC-MS) to determine the concentration of antimicrobial compounds in animal sera; plasma; and/or tissue samples.
  • Perform pharmacokinetic modeling of antimicrobial compounds and develop dosing schedules to achieve therapeutic MICs.
  • Prepare PK data/analysis for 10 technical reports that will be sent to the customers as well as the funding agencies.
  • Therapeutics/compounds will be tested against Bacillus anthracis spores and cells (anthrax); Yersinia pestis (plague); Burkholderia mallei (glanders); Burkholderia pseudomallei (melioidosis); and Francisella tularensis (tularemia) in a BSL-3 containment suite
  • Support animal studies and participate in challenge of various species of lab animals with viable cultures of bacterial agents. Support will include the collection of bodily fluid and tissue samples; euthanasia; necropsy; administration of therapeutic compounds and vaccines orally and by intraperitoneal; intramuscular; and subcutaneous injections.
  • Optimize drug formulation and drug delivery to improve in vivo performance.
  • Validate antibiotic comparator compounds for which known PK data has been published.
  • Prepare antimicrobials and vaccines for administration to animals in support of therapeutic experiments.
  • Maintain necessary levels of documented training for working with laboratory animals; to include GLP studies.

Job Requirements

  • 8+ years of related experience in scientific research, analysis and/or engineering.
  • Based on customer requirements, US citizenship is a requirement with the ability to obtain a favorable T3 investigation and Biological Personnel Reliability Program (BPRP) enrollment. 

As a trusted systems integrator for more than 50 years, General Dynamics Information Technology provides information technology (IT), systems engineering, professional services and simulation and training to customers in the defense, federal civilian government, health, homeland security, intelligence, state and local government and commercial sectors.With approximately 32,000 professionals worldwide, the company delivers IT enterprise solutions, manages large-scale, mission-critical IT programs and provides mission support services.GDIT is an Equal Opportunity/Affirmative Action Employer - Minorities/Females/Protected Veterans/Individuals with Disabilities.